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Bart Deplancke

Bart Deplancke graduated as a Biochemical Engineer at Ghent University (Belgium, 1998) after which he pursued doctoral studies in Immunobiology at the University of Illinois (USA) and postdoctoral work in regulatory genomics at the Harvard and UMass Medical Schools. In 2007, he established his lab at the EPFL School of Life Sciences where he is now Full Professor and Vice-Dean of Innovation and is developing new experimental and computational approaches to study the biology of the genome. The Deplancke Lab has by now built a sizeable toolkit, involving microfluidics, high-throughput sequencing, and single cell genomics, to address questions pertaining to the origin, diversity and function of stromal cells in adipose tissue as well as to how genomic variation affects molecular and organismal diversity with a specific focus on metabolic phenotypes. In 2013, he became a Swiss Institute of Bioinformatics Group Leader and in 2017 was elected to the National Research Council of the Swiss National Science Foundation. He is also the co-founder of two Biotech companies (Genohm, Acquired by Agilent in 2018; and Alithea Genomics).

Selected publications

ChromatinHD connects single-cell DNA accessibility and conformation to gene expression through scale-adaptive machine learningNon-coding variants impact cis-regulatory coordination in a cell type-specific mannerContext transcription factors establish cooperative environments and mediate enhancer communicationChromatin modules and their implication in genomic organization and gene regulationA leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleationSimplified Drop-seq workflow with minimized bead loss using a bead capture and processing microfluidic chip.ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer.
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ESR Student

 Olga Pushkareva (ESR5)

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Marie CurieThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 860002. The information contained in this website reflects only the authors’ view. REA and EC are not responsible for any use that may be made of this information.

Joris van Arensbergen (Supervisor) Wouter De Laat (Supervisor)